Matched vs nonmatched placebos in a platform trial: The TOGETHER randomized clinical trial experience

Clinical Trials•2024

Authors

G Reis, EASM Silva, DCM Silva, LJ Thabane, AC Ferreira, VEG de Souza-Campos, APM Almeida, AM Nogueira, EDS Callegari, ADF de Figueiredo-Neto, JI Forrest, JH Park, CS Wiens, CM Guo, K Thorlund, EJ Mills

TOGETHER Trial

Abstract

Background: Platform trials testing multiple interventions raise questions about placebo matching. We examined the impact of matched versus nonmatched placebos on trial outcomes and participant blinding in the TOGETHER platform trial for COVID-19 treatments.

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